Expression and Clinical Significance of CD38 inthe Blood of Patients with Lupus Nephritis

doi:10. 3969/j. issn. 2096-2266. 2021. 10. 008

Abstract

Abstract:

Objective：The expression and clinical significance of CD38 inthe blood of patients with lupus nephritis （LN） were analyzed to predict the involvement of CD38 inthe LN signaling pathway.Methods： The expression difference of CD38 inthe blood of patients with LN was analyzed and visualized by R language. Pearson correlation analysis and multiple linear regression analysis were carried out by SPSS 23.0 software. GSEA 4.1.0software was used for enrichment analysis of CD38. Results： After immunotherapy， CD38 expression in the blood of patients with LN decreased significantly （P < 0.05）. With the prolongation of immunotherapy time， CD38 expression in the blood of patients with LN was gradually significantly down-regulated （P < 0.05）. CD38 expression was significantly correlated with ds DNA antibody and SLEDAI score （P < 0.05）， and was the main factor affecting SLEDAI score. CD38 is mainly concentrated on the MARK signaling pathway， WNT signaling pathway and JAK-STAT signaling pathway. Conclusion： CD38 can be used as a biomarker for early diagnosis or severity of symptoms in patients with LN， and as a specific target for potential biologic agents.

Key words: font-family:", ">lupus nephritisfont-family:宋体, ">；font-family:", "> CD38font-family:宋体, ">；font-family:", "> biomarker

CLC Number:

R593.24

Cui Daolin, Chen Chunli.

Expression and Clinical Significance of CD38 inthe Blood of Patients with Lupus Nephritis [J]. Journal of Dali University, 2021, 6(10): 41-.

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